cognitive
Selank / Semax
A dual nootropic formulation combining a tuftsin-derived anxiolytic heptapeptide with an ACTH-fragment cognitive enhancer — studied for complementary modulation of BDNF expression, GABAergic tone, and monoamine neurotransmission.
For research and laboratory use only. Not for human consumption.
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Certificate of Analysis
Certificate of Analysis
COA documentation is being prepared for this product.
Contact research@roehnrx.com for batch-specific testing data.
Research Overview
About Selank / Semax
Selank is a synthetic heptapeptide derived from the endogenous immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg), extended with three additional residues (Pro-Gly-Pro) to confer CNS bioactivity and resistance to enzymatic degradation. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, it has been investigated for anxiolytic properties mediated through GABAergic system modulation, serotonin metabolism regulation, and BDNF upregulation in limbic structures.
Semax is a synthetic heptapeptide based on the ACTH(4-10) fragment, engineered for enhanced metabolic stability and CNS penetration. Research has focused on its stimulation of BDNF and NGF synthesis in cortical and hippocampal neurons, its modulation of dopaminergic and serotonergic neurotransmission, and neuroprotective effects documented in ischemia models.
The combination targets complementary cognitive dimensions — Selank's anxiolytic, stress-buffering profile alongside Semax's pro-cognitive, attention-enhancing properties — offering a dual approach to central nervous system research. ROEHN supplies this blend at 99% HPLC-verified purity (each component), typically administered intranasally to leverage direct olfactory and trigeminal nerve pathways into the CNS.
