metabolic
NAD+
The essential dinucleotide coenzyme at the nexus of cellular energy production, sirtuin-mediated gene regulation, and PARP-dependent DNA repair — a foundational compound in longevity and metabolic health research.
For research and laboratory use only. Not for human consumption.
Subscribe & save: $84
Quantity
Add 1 more to save 10% per unit
Technical Data
Specifications
Technical Details
Bulk Pricing
Volume Pricing Guide
Quality Assurance
Certificate of Analysis
Certificate of Analysis
COA documentation is being prepared for this product.
Contact research@roehnrx.com for batch-specific testing data.
Research Overview
About NAD+
Nicotinamide adenine dinucleotide (NAD+) is a dinucleotide coenzyme present in every living cell, serving as an indispensable electron carrier across hundreds of redox reactions in glycolysis, the citric acid cycle, and oxidative phosphorylation. Its role extends beyond metabolism: NAD+ is consumed as a substrate by sirtuins (class III histone deacetylases governing gene expression and stress responses), poly-ADP-ribose polymerases (PARPs critical to DNA repair), and CD38/CD157 glycohydrolases — enzymes collectively central to cellular maintenance and aging biology.
Tissue NAD+ concentrations decline measurably with age, a phenomenon now considered a hallmark of metabolic aging. This decline is associated with impaired mitochondrial function, reduced sirtuin activity, compromised DNA repair capacity, and increased susceptibility to metabolic disease. Parenteral NAD+ administration — intravenous and subcutaneous — is studied as a direct strategy to elevate tissue levels beyond what oral precursor supplementation achieves.
ROEHN provides NAD+ at 99% HPLC-verified purity as a lyophilized powder. Research protocols have examined its effects on bioenergetics, cognitive function, metabolic biomarkers, and cellular senescence endpoints, establishing it as one of the most actively investigated molecules in the longevity research landscape.
